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荣获金球奖最佳戏剧类电视剧集！荣获艾美奖最佳戏剧类影集选角！萤幕演员公会最佳戏剧类电视剧集！故事延续第三季精采的剧情。西雅图恩典医院因为这些实习医生之间的爱恨情仇，变得更加热闹更有可看性！第三季中格蕾终於摆脱了德瑞克和兽医间的三角恋情，依自己的心意选择了所爱的人。伊兹在丹尼死后一厥不振，甚至想要放弃成为外科医生的梦想。克莉丝汀知道了柏克的秘密后，一直企图帮他掩饰。而乔治和性感火辣的住院医师之间的关係变得更迷离。而艾立克斯竟发现自己还是爱著伊兹！另外，马克为了艾蒂森竟也来到了西雅图恩典医院工作。Meredith和Cristina蜜月归来（买好的机票不好浪费~），Burke已经消失无踪。去年的实习医生Meredith, Cristina, Izzie和Alex，已经获得了正式驻院医生的资格，并且有了自己的跟班，一群初出茅庐，青涩而稚嫩的实习医生。当中，有去年考试不及格的George，还有Meredith素未谋面的妹妹Lexie Grey。今天，他们将要处理一宗三车连环相撞的交通意外，大量的伤者让新来的实习手足无措，目瞪口呆。另一边厢，Derek和Meredith的感情陷入僵局，有可能他们都会和新来的同事有新的感情发展。Bailey对于Callie成为驻院总医生感到气愤，也许她一时三刻还难以接受自己现在要向Callie汇报工作。Richard留任外科主任，仍然是大家的老大~(简介转自YDY)After failing his exam, George reluctantly faces his first day reliving his internship among a sea of fresh faces. Meanwhile, Cristina, Meredith, Izzie and Alex are in charge of their own interns and George is assigned to Meredith.Neither Cristina or Meredith have heard from her exes since the wedding, and they don't seem overly concerned, which astounds Izzie, who is counting every day since she last spoke to George. George asks to talk to Meredith but before he can get her alone, the rest of the new interns show up in the hall and are shooed off by the residents. George gives up and joins the interns. Cristina nicknames him "Bambi," saying he needs to learn how to deal with his new situation.赶，赶不走。潜入京城就为了掳一女子？众臣纷纷嗤笑不已。"Then they launched an attack on position 149 as soon as they completed the assembly?" I asked.孤儿石惠被孙大凯寡母收养，为报答孙母养育之恩，石惠与孙大凯结合。石惠发现孙大凯嗜赌，在与孙大凯离婚后又被孙大凯强奸，孙大凯因此入狱，此后，石惠接受了崔文军的求爱。面对崔母的挑剔和事业的坎坷，石惠顽强拼搏，并生下女儿瑶瑶。崔母意外发现瑶瑶原是孙大凯的女儿，要求崔文军立刻离婚。石惠带瑶瑶离开了石惠艰难创业，服装生意蒸蒸日上，崔母重病，石惠在身旁精心照顾。崔母深受感动，反过来撮合石惠和崔文军复婚。瑶瑶得了重病必须换肝，符合条件的崔文军逃走，石惠被迫找到孙大凯。换肝手术成功，但瑶瑶失明了。一直暗恋石惠的大款潘国庆破产后自杀，石惠将他救下来，却因经济纠纷被调查，孙大凯出面证实，其实是林芳所为，石惠被洗脱嫌疑。石惠的大爱与宽容感动了所有人，潘国庆也在石惠的劝说下去寻找一直深爱他的林芳。　　这日，CID峰（谢霆锋 饰）和女友Miss张（张柏芝 饰）正因张母反对二人在一起而苦恼，老夫子和大番薯因得罪黑社会老大金爷被追杀，引发了一场大车祸。车祸中峰和Miss张失去了记忆，痊愈后两人形同陌路。第二季中，他们将与日益恼怒的家人一起面对"新平常"，同时还要应对"虚拟好莱坞"世界，和自己越发脆弱的自尊心。